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Neurodegenerative Disease

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Neuroplasticity

Effects and Mechanisms of Exercise on Brain-derived Neurotrophic Factor Levels and Clinical Outcomes in People with Parkinson’s Disease: A Systematic Review and Meta-analysis 4045

Thursday, October 31, 2024
2:30 PM – 3:30 PM  
Location:  ROOM: Cortez B REGION: Tower Lobby Level >>> DIRECTIONS: From ACRM Registration desk, face the elephants and turn right. Proceed past the lobby elevators and turn right to enter the West Wing. Proceed down the corridor, turn right and then left. Proceed past the restrooms to the end of the hall and turn right. Proceed down the corridor on the left. Cortez B is the last room on the left.
The purpose of the present systematic review and meta-analysis is to give an overview of the mechanisms and effects of exercise therapy on BDNF levels and clinical outcomes in PD, in order to bring these insights into the clinical context of physical medicine and rehabilitation for people living with PD. For details see the open access publication below:

Kaagman DGM, van Wegen EEH, Cignetti N, Rothermel E, Vanbellingen T, Hirsch MA. Effects and Mechanisms of Exercise on Brain-Derived Neurotrophic Factor (BDNF) Levels and Clinical Outcomes in People with Parkinson’s Disease: A Systematic Review and Meta-Analysis. Brain Sciences. 2024; 14(3):194. https://doi.org/10.3390/brainsci14030194

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Learning Objectives:

  • List at least 3 biologic mechanisms of probable exercise-induced neuroplasticity in the rehabilitation of patients with Parkinson's disease
  • Identify components of a systematic review and meta-analysis.
  • List 3 standardized outcome measures responsive to exercise interventions used in the present meta-analysis.
  • List at least 3 biologic mechanisms of probable exercise-induced neuroplasticity in the rehabilitation of patients with Parkinson's disease
Disclosure(s):
Erwin E. H van Wegen, PhD: No financial relationships to disclose
Mark A. Hirsch, PhD, FACRM, FPRD: Carolinas Rehabilitation: Employment (full or part time) (Ongoing); Dutch Brain Foundation: Contracted Research (Principal Investigators must provide information, even if received by the institution) (Ongoing); Merz Neurosciences: Contracted Research (Principal Investigators must provide information, even if received by the institution) (Ongoing); National Institute on Disability Independent Living and Rehabilitation Research: Contracted Research (Principal Investigators must provide information, even if received by the institution) (Ongoing); NIH: Contracted Research (Principal Investigators must provide information, even if received by the institution) (Ongoing); Parkinson Foundation: Advisory Board (Ongoing); Wake CTSI: Contracted Research (Principal Investigators must provide information, even if received by the institution) (Ongoing); World Parkinson Congress: Speaker/Honoraria (Terminated, November 23, 2023)
Tim Vanbellingen, PhD: No financial relationships to disclose